DOES INJECTION OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKERS BEFORE THIOPENTONE AFFECT THEIR SPEED OF ONSET?
نویسندگان
چکیده
منابع مشابه
Does injection of non-depolarizing neuromuscular blockers before thiopentone affect their speed of onset? A study of tubocurarine and vecuronium.
In an open sequential pharmacodynamic study in 40 patients, the rate of onset of neuromuscular blockade using tubocurarine or vecuronium was measured. Comparison was made between groups of 10 patients who received thiopentone followed by either blocker and a "reverse" sequence where the blocker was injected before thiopentone. There was a small difference between groups, amounting to a few seco...
متن کاملFactors that affect the onset of action of non-depolarizing neuromuscular blocking agents
Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric anesthesia, and its purpose is to obtain a stable airway, adequate depth of anesthesia, and appropriate respiration within a short period of time without causing irri...
متن کاملErratum: Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents
[This corrects the article on p. 500 in vol. 70, PMID: 29046769.].
متن کاملPharmacodynamics of non-depolarizing neuromuscular blocking agents.
When a clinical dose of a competitive neuromuscular blocking drug is given I.V. to a patient, a period of latency is followed by a progressive onset of blockade until a maximum is reached after several minutes. Thereafter, the intensity of block declines gradually. The precise relationship between the dose of drug and the time-course of the effect is complex, being dependent upon both pharmacok...
متن کاملAdministration of magnesium sulphate before rocuronium: effects on speed of onset and duration of neuromuscular block.
The speeds of onset of pancuronium, atracurium and vecuronium are increased by prior administration of magnesium sulphate. A prospective, randomized, double-blind, controlled, clinical study was performed to examine the effects of prior i.v. administration of magnesium sulphate 60 mg kg-1 on the neuromuscular blocking effects of rocuronium 0.6 mg kg-1 during isoflurane anaesthesia. Neuromuscula...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1987
ISSN: 0007-0912
DOI: 10.1093/bja/59.11.1451